Derya R Shimshek Selected Research

Amyloid (Amyloid Fibrils)

10/2019	Early Aβ reduction prevents progression of cerebral amyloid angiopathy.
1/2019	The β-secretase (BACE) inhibitor NB-360 in preclinical models: From amyloid-β reduction to downstream disease-relevant effects.
11/2018	The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.
1/2018	BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology.
1/2018	Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6.
6/2017	Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition.
2/2016	Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice.
1/2016	Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice.
9/2015	A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.
1/2014	Imaging of cerebrovascular pathology in animal models of Alzheimer's disease.

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Derya R Shimshek Research Topics

Disease

15	Parkinson Disease (Parkinson's Disease) 11/2021 - 04/2010
10	Alzheimer Disease (Alzheimer's Disease) 12/2020 - 09/2015
4	Neuroinflammatory Diseases 01/2019 - 01/2013
3	Synucleinopathies 12/2020 - 04/2010
3	Dementia (Dementias) 01/2019 - 09/2015
2	Disease Progression 11/2021 - 01/2016
2	Demyelinating Diseases (Demyelinating Disease) 01/2021 - 01/2018
2	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2020 - 01/2016
2	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2016 - 01/2014
1	Parkinsonian Disorders (Parkinsonism) 01/2022
1	Multiple Sclerosis 01/2021
1	Amyloidosis 12/2020
1	Memory Disorders (Memory Loss) 12/2020
1	Familial Cerebral Amyloid Angiopathy 10/2019
1	Amyloid Plaque 11/2018
1	Asymptomatic Diseases 11/2018
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2018
1	Neoplasms (Cancer) 01/2014
1	Leprosy (Hansen's Disease) 01/2014
1	Huntington Disease (Huntington's Disease) 01/2012
1	Gliosis 01/2012
1	Seizures (Absence Seizure) 11/2004

Drug/Important Bio-Agent (IBA)

11	Phosphotransferases (Kinase)IBA 01/2022 - 11/2011
10	Amyloid (Amyloid Fibrils)IBA 10/2019 - 01/2014
9	Leucine (L-Leucine)FDA Link 11/2021 - 11/2011
9	Proteins (Proteins, Gene)FDA Link 01/2019 - 11/2011
8	SynucleinsIBA 11/2021 - 01/2011
3	EnzymesIBA 01/2019 - 06/2017
2	CuprizoneIBA 01/2021 - 01/2018
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2019 - 02/2016
2	NB-360IBA 01/2019 - 09/2015
2	Pharmaceutical PreparationsIBA 01/2018 - 01/2018
1	ParvalbuminsIBA 12/2020
1	Amyloid beta-PeptidesIBA 12/2020
1	Peptides (Polypeptides)IBA 10/2019
1	UmibecestatIBA 11/2018
1	Peptide Hydrolases (Proteases)FDA Link 01/2018
1	Macrophage Colony-Stimulating Factor Receptor (Receptor, Macrophage Colony Stimulating Factor)IBA 01/2018
1	4- (2- (2- hydroxycyclohexylamino)benzothiazol- 6- yloxy)pyridine- 2- carboxylic acid methylamideIBA 01/2018
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 01/2016
1	Biomarkers (Surrogate Marker)IBA 01/2016
1	Formaldehyde (Formol)FDA Link 01/2015
1	Leucine-Rich Repeat ProteinsIBA 01/2012
1	UbiquitinIBA 01/2012
1	Ubiquitin Thiolesterase (Ubiquitin Carboxy-Terminal Hydrolase)IBA 01/2012
1	alpha-SynucleinIBA 04/2010
1	Molecular Chaperones (Chaperone, Molecular)IBA 04/2010
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 04/2010
1	AMPA Receptors (AMPA Receptor)IBA 11/2004
1	Glutamate Receptors (Glutamate Receptor)IBA 11/2004
1	glutamate receptor type BIBA 11/2004

Therapy/Procedure

5	Therapeutics 11/2021 - 01/2016
1	Precision Medicine 01/2019
1	Immunotherapy 01/2016